Which Presonus studio monitors are best for a beginner home studio?

The Presonus Eris E5 monitors are a great option. Not only are they compact and affordable, but they are a professional level speaker, so there is no need to upgrade your speakers as you become more experienced.

Which Presonus audio interface is best for a beginner home studio?

The Presonus iTwo is a good option as it not only features high quality preamps and a simple user interface, but it also includes the Studio One Artist recording package. There is also a Recording Package version of the iTwo which includes headphones, a microphone and all the cables required. The iTwo is also compatible with iPhones and iPads and is a perfect option for recording vocals and instruments to your favourite recording studio apps.